Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Responses to the H-2Kba mutant involve recognition of syngeneic Ia molecules.

Nature - 1 Jan 2000

Weinberger O, Germain R N, Burakoff S J

Abstract excerpt

Conventional antigens appear to be recognized by T lymphocytes only when associated with major histocompatibility complex (MHC) antigens. Using antigen-specific proliferation as a model for helper T lymphocytes, it has been demonstrated that Ly1+T cells recognize antigen presented in association with syngeneic Ia molecules. In contrast to responses to conventional antigens, however, a large number of studies have...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytotoxicity, Immunologic
Share to H-2 Antigens
Share to Histocompatibility Antigens Class II

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Lymphocyte Activation

Share to Mutation

Share to T-Lymphocytes

Share to T-Lymphocytes, Helper-Inducer

Source

Identifiers

PMID: 6220226
DOI: 10.1038/302429a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Responses to the H-2Kba mutant involve recognition of syngeneic Ia molecules.PMID 6220226Read ↗

A single amino acid substitution in the H-2Kb molecule generates a defined allogeneic epitope.Semantic proximity Read ↗

Mutations in the alpha 1 domain of a class I gene define residues important for specific allorecognition.Semantic proximity Read ↗

HLA-DRB1 amino acid disparity is the major stimulus of interleukin-2 production by alloreactive helper T-lymphocytes.Semantic proximity Read ↗

NK-mediated elimination of mutant lymphocytes that have lost expression of MHC class I molecules.Semantic proximity Read ↗

Unique biochemical properties of a mutant MHC class I molecule, H-2Ksm1.Semantic proximity Read ↗

Allogeneic recognition of class I molecules: anti-H-2Ld repertoire of H-2b mice includes T cells recognizing mutant class II H-2b (Abm12) molecules.Semantic proximity Read ↗

Role of endogenous peptides in murine allogenic cytotoxic T cell responses assessed using transfectants of the antigen-processing mutant 174xCEM.T2.Semantic proximity Read ↗

Biochemical analysis of related, independently arising histocompatibility mutants: bm17 and KB-98 enlarge the "bg series" of H-2Kb mutants.Semantic proximity Read ↗

On naming H2 haplotypes: functional significance of MHC class Ib alleles.Semantic proximity Read ↗

Recognition of a single amino acid change on the surface of a major transplantation antigen is in the context of self peptide.Semantic proximity Read ↗

Allelic polymorphisms at the H-2A and HLA-DQ loci influence the response of murine lymphocytes to the Mycoplasma arthritidis superantigen MAM.Semantic proximity Read ↗

Presentation of abundant endogenous class II DR-restricted antigens by DM-negative B cell lines.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.