Article
Impaired antibody responses in H-2Ab mice.
Journal of immunology (Baltimore, Md. : 1950) - 15 Aug 1998
Gustavsson S, Hjulström-Chomez S, Lidström B M, Ahlborg N, Andersson R, Heyman B
Abstract excerpt
In murine in vivo systems, Ags administered in physiologic solutions together with specific IgE induce a significantly higher Ab response than Ags administered alone. In vitro, IgE in complex with Ag enhances B cell-mediated presentation of the Ag to T cells. Both phenomena require an intact low affinity receptor for IgE (Fc epsilon RII/CD23), suggesting that the effect on in vivo Ab responses is caused by...
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