Genetic polymorphisms of Q region genes from wild-derived mice: implications for Q region evolution.

doi:10.1007/BF02115005

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Article

Genetic polymorphisms of Q region genes from wild-derived mice: implications for Q region evolution.

Immunogenetics - 1 Jan 1990

Tine J A, Walsh A, Rathbun D, Leonard L, Wakeland E K, Dilwith R, Flaherty L

Abstract excerpt

Both serological and DNA sequence analyses were performed to determine the extent of genetic polymorphism in Q region genes. A panel of Qa-2-specific monoclonal antibodies (mAbs) was tested on 35 wild-derived and inbred mouse strains. Members of this reagent panel recognize multiple and distinct epitopes on the Qa-2-bearing molecule(s). Although quantitative variations in Qa-2 levels were observed, no structural...

Topics

Aging
Animals
Animals, Wild
Antibodies, Monoclonal
Base Sequence
Biological Evolution
Cell Cycle
Genetic Variation
Histocompatibility Antigens Class I
Mice
Mice, Inbred Strains

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Multigene Family

Polymerase Chain Reaction

Polymorphism, Genetic

Sequence Homology, Nucleic Acid

Sex Characteristics

Source

Open in PubMed

Identifiers

PMID: 2370077
DOI: 10.1007/BF02115005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2370077-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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