Article
Genetic polymorphisms of Q region genes from wild-derived mice: implications for Q region evolution.
Immunogenetics - 1 Jan 1990
Tine J A, Walsh A, Rathbun D, Leonard L, Wakeland E K, Dilwith R, Flaherty L
Abstract excerpt
Both serological and DNA sequence analyses were performed to determine the extent of genetic polymorphism in Q region genes. A panel of Qa-2-specific monoclonal antibodies (mAbs) was tested on 35 wild-derived and inbred mouse strains. Members of this reagent panel recognize multiple and distinct epitopes on the Qa-2-bearing molecule(s). Although quantitative variations in Qa-2 levels were observed, no structural...
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