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Article

Mutations in yeast U5 snRNA alter the specificity of 5' splice-site cleavage.

Cell - 5 Apr 1991

Newman A, Norman C

Abstract excerpt

Recognition of 5' splice sites in pre-mRNA splicing is achieved in part by base pairing with U1 snRNA. We have used interactive suppression in the yeast Saccharomyces cerevisiae to look for other factors involved in 5' splice-site recognition. This approach identified an extragenic suppressor that activates a cryptic 5' splice site. The suppressor is a gene for U5 snRNA (snR7) with a single base mutation in a...

Topics

Base Composition
Base Sequence
Genes, Fungal
Genes, Suppressor
Introns
Molecular Sequence Data
Mutation
Nucleic Acid Conformation
RNA Precursors
RNA Processing, Post-Transcriptional
RNA Splicing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

RNA, Fungal

RNA, Small Nuclear

Saccharomyces cerevisiae

Substrate Specificity

Source

Identifiers

PMID: 2013092
DOI: 10.1016/0092-8674(91)90413-s

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2013092-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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