Article
Genetic interaction between U6 snRNA and the first intron nucleotide in Saccharomyces cerevisiae.
RNA (New York, N.Y.) - 1 Feb 1998
Luukkonen B G, Séraphin B
Abstract excerpt
Nuclear pre-mRNA splicing necessitates specific recognition of the pre-mRNA splice sites. It is known that 5' splice site selection requires base pairing of U6 snRNA with intron positions 4-6. However, no factor recognizing the highly conserved 5' splice site GU has yet been identified. We have tested if the known U6 snRNA-pre-mRNA interaction could be extended to include the first intron nucleotides and the...
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