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Article

Interactions of the yeast U6 RNA with the pre-mRNA branch site.

RNA (New York, N.Y.) - 1 Nov 1996

McPheeters D S

Abstract excerpt

The small nuclear RNA (snRNA) components of the spliceosome have been proposed to catalyze the excision of introns from nuclear pre-mRNAs. If this hypothesis is correct, then the snRNA components of the spliceosome may interact directly with the reactive groups of pre-mRNA substrates. To explore this possibility, a genetic screen has been used to identify potential interactions between the U6 RNA and the pre-mRNA...

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Identifiers

PMID: 8903342
PMCID: PMC1369441

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Interactions of the yeast U6 RNA with the pre-mRNA branch site.PMID 8903342Read ↗

Identification of a U2/U6 helix la mutant that influences 3' splice site selection during nuclear pre-mRNA splicing.Semantic proximity Read ↗

The conserved central domain of yeast U6 snRNA: importance of U2-U6 helix Ia in spliceosome assembly.Semantic proximity Read ↗

Mutations in U6 snRNA that alter splice site specificity: implications for the active site.Semantic proximity Read ↗

Invariant U2 RNA sequences bordering the branchpoint recognition region are essential for interaction with yeast SF3a and SF3b subunits.Semantic proximity Read ↗

Allele-specific genetic interactions between Prp8 and RNA active site residues suggest a function for Prp8 at the catalytic core of the spliceosome.Semantic proximity Read ↗

Genetic interactions between the yeast RNA helicase homolog Prp16 and spliceosomal snRNAs identify candidate ligands for the Prp16 RNA-dependent ATPase.Semantic proximity Read ↗

The Prp18 protein stabilizes the interaction of both exons with the U5 snRNA during the second step of pre-mRNA splicing.Semantic proximity Read ↗

U6 snRNA function in nuclear pre-mRNA splicing: a phosphorothioate interference analysis of the U6 phosphate backbone.Semantic proximity Read ↗

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Evidence for an essential non-Watson-Crick interaction between the first and last nucleotides of a nuclear pre-mRNA intron.Semantic proximity Read ↗

An RNA-dependent ATPase associated with U2/U6 snRNAs in pre-mRNA splicing.Semantic proximity Read ↗

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