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Article

Involvement of U6 snRNA in 5' splice site selection.

Science (New York, N.Y.) - 24 Dec 1993

Kandels-Lewis S, Séraphin B

Abstract excerpt

Two models describing the interaction between U6 small nuclear RNA (snRNA) and the 5' splice site of introns have been proposed on the basis of cross-linking experiments. Here it is shown that a conserved sequence present in U6 snRNA forms base pairs with conserved nucleotides at the 5' splice junction and that this interaction is involved in 5' splice site choice. These results demonstrate a specific function...

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Source

Identifiers

PMID: 8266100
DOI: 10.1126/science.8266100

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Involvement of U6 snRNA in 5' splice site selection.PMID 8266100Read ↗

Mutations in U6 snRNA that alter splice site specificity: implications for the active site.Semantic proximity Read ↗

U1 snRNA promotes the selection of nearby 5' splice sites by U6 snRNA in mammalian cells.Semantic proximity Read ↗

Protein-free spliceosomal snRNAs catalyze a reaction that resembles the first step of splicing.Semantic proximity Read ↗

A tertiary interaction detected in a human U2-U6 snRNA complex assembled in vitro resembles a genetically proven interaction in yeast.Semantic proximity Read ↗

Genetic interaction between U6 snRNA and the first intron nucleotide in Saccharomyces cerevisiae.Semantic proximity Read ↗

Interactions of the yeast U6 RNA with the pre-mRNA branch site.Semantic proximity Read ↗

Mutation in the U2 snRNA influences exon interactions of U5 snRNA loop 1 during pre-mRNA splicing.Semantic proximity Read ↗

The conserved central domain of yeast U6 snRNA: importance of U2-U6 helix Ia in spliceosome assembly.Semantic proximity Read ↗

Invariant U2 snRNA nucleotides form a stem loop to recognize the intron early in splicing.Semantic proximity Read ↗

Sequences upstream of the branch site are required to form helix II between U2 and U6 snRNA in a trans-splicing reaction.Semantic proximity Read ↗

Rearrangement of competing U2 RNA helices within the spliceosome promotes multiple steps in splicing.Semantic proximity Read ↗

U5 snRNA interactions with exons ensure splicing precisionSemantic proximity Read ↗

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