Article
Analysis of the neurofibromatosis 2 gene in human ependymomas and astrocytomas.
Cancer research - 1 Jan 1994
Rubio M P, Correa K M, Ramesh V, MacCollin M M, Jacoby L B, von Deimling A, Gusella J F, Louis D N
Abstract excerpt
Ependymomas and astrocytomas commonly have allelic losses of chromosome 22q, which suggests the presence of a glioma tumor suppressor gene on 22q. A candidate tumor suppressor gene on 22q is the neurofibromatosis 2 (NF2) gene since NF2 patients have an increased susceptibility to ependymomas and astrocytomas. Using single strand conformation polymorphism analysis and direct DNA sequencing, we screened 8...
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