Analysis of the neurofibromatosis 2 gene in human ependymomas and astrocytomas.

Article

Analysis of the neurofibromatosis 2 gene in human ependymomas and astrocytomas.

Cancer research - 1 Jan 1994

Rubio M P, Correa K M, Ramesh V, MacCollin M M, Jacoby L B, von Deimling A, Gusella J F, Louis D N

Abstract excerpt

Ependymomas and astrocytomas commonly have allelic losses of chromosome 22q, which suggests the presence of a glioma tumor suppressor gene on 22q. A candidate tumor suppressor gene on 22q is the neurofibromatosis 2 (NF2) gene since NF2 patients have an increased susceptibility to ependymomas and...

Topics

Astrocytoma
Chromosome Deletion
Chromosomes, Human, Pair 22
DNA, Neoplasm
Ependymoma
Genes, Neurofibromatosis 2
Humans
Mutation
Sequence Analysis, DNA

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.