Article
Exon scanning for mutation of the NF2 gene in schwannomas.
Human molecular genetics - 1 Mar 1994
Jacoby L B, MacCollin M, Louis D N, Mohney T, Rubio M P, Pulaski K, Trofatter J A, Kley N, Seizinger B, Ramesh V
Abstract excerpt
Family studies and tumor analyses have combined to indicate that neurofibromatosis 2 (NF2), a disorder characterized by multiple benign tumors of the nervous system, and sporadic non-inherited forms of the same tumor types are both caused by inactivation of a tumor suppressor gene located in 22q12. Recently, the gene encoding merlin, a novel member of a family of cytoskeleton-associated proteins, was identified...
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