Article
Analysis of the NF2 gene in oligodendrogliomas and ependymomas.
Cancer genetics and cytogenetics - 1 Apr 2002
Alonso M Eva, Bello M Josefa, Arjona Dolores, Gonzalez-Gomez Pilar, Lomas Jesus, de Campos Jose M, Kusak M Elena, Isla Alberto, Rey Juan A
Abstract excerpt
Allelic losses of chromosome 22 are commonly found in ependymomas and oligodendrogliomas, suggesting that at least one tumor suppressor gene on chromosome 22 must be inactivated during the multistep process of tumorigenesis in these glial tumors. The neurofibromatosis 2 gene (NF2) located at 22q12, is a candidate tumor suppressor gene potentially involved in the pathogenesis of gliomas. Because there have been...
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