Six novel mutations in the NF2 tumor suppressor gene.

doi:10.3892/ijo.12.4.935

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Article

Six novel mutations in the NF2 tumor suppressor gene.

International journal of oncology - 1 Apr 1998

Leone P E, Bello M J, Mendiola M, Vaquero J, Sarasa J L, Kusak M E, De Campos J M, Pestana A, Rey J A

Abstract excerpt

Six novel mutations were identified in the NF2 tumor suppressor gene in a panel of meningiomas and neurinomas. Screening was performed using a combination of single-strand conformation polymorphism and heteroduplex analyses on polymerase chain reaction-amplified DNA from tumors and matched periph...

Topics

Chromosome Aberrations
Genes, Tumor Suppressor
Humans
Membrane Proteins
Mutation
Neurofibromin 2
Polymorphism, Single-Stranded Conformational

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