Article
Molecular genetic analysis of ependymal tumors. NF2 mutations and chromosome 22q loss occur preferentially in intramedullary spinal ependymomas.
The American journal of pathology - 1 Aug 1999
Ebert C, von Haken M, Meyer-Puttlitz B, Wiestler O D, Reifenberger G, Pietsch T, von Deimling A
Abstract excerpt
Ependymal tumors are heterogeneous with regard to morphology, localization, age at first clinical manifestation, and prognosis. Several molecular alterations have been reported in these tumors, including allelic losses on chromosomes 10, 17, and 22 and mutations in the NF2 gene. However, in contrast to astrocytic gliomas, no consistent molecular alterations have been associated with distinct types of ependymal...
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