Article
Analysis of the neurofibromatosis type 2 gene in different human tumors of neuroectodermal origin.
Human genetics - 1 May 1996
De Vitis L R, Tedde A, Vitelli F, Ammannati F, Mennonna P, Bono P, Grammatico B, Grammatico P, Radice P, Bigozzi U, Montali E, Papi L
Abstract excerpt
The autosomal dominant syndrome neurofibromatosis type 2 (NF2) is characterized by the development of bilateral vestibular schwannomas, meningiomas, ependymomas and gliomas. The NF2 gene, recently isolated from chromosome 22, is mutated in both sporadic and NF2 tumors such as schwannomas, meningi...
Topics
- Central Nervous System Neoplasms
- Chromosomes, Human, Pair 22
- Ependymoma
- Exons
- Genes, Neurofibromatosis 2
- Glioma
- Humans
- Melanoma
- Meningeal Neoplasms
- Meningioma
- Mutation
- Neuroectodermal Tumors, Primitive, Peripheral
- Neuroma, Acoustic
- Point Mutation
- Polymorphism, Single-Stranded Conformational