Article
Predominant occurrence of somatic mutations of the NF2 gene in meningiomas and schwannomas.
Genes, chromosomes & cancer - 1 Jul 1995
Mérel P, Hoang-Xuan K, Sanson M, Moreau-Aubry A, Bijlsma E K, Lazaro C, Moisan J P, Resche F, Nishisho I, Estivill X
Abstract excerpt
The NF2 gene is a putative tumor-suppressor gene that, when it is altered in the germline, causes neurofibromatosis type 2, a tumor-susceptibility disease that mainly predisposes to schwannomas and meningiomas. The recent isolation of the NF2 gene on chromosome 22 allows the identification of somatic mutations in human tumors. We have searched for mutations of the NF2 gene in 331 primary human tumors using a...
Topics
- Brain Neoplasms
- Chromosomes, Human, Pair 22
- Genes, Neurofibromatosis 2
- Humans
- Membrane Proteins
- Meningeal Neoplasms
- Meningioma
- Mutation
- Neurilemmoma
- Neurofibromin 2