Article
Using mitotic recombinant mutant clonal lymphocytes for physical mapping of polymorphic loci on the short arm of human chromosome 6.
Genomics - 1 Sept 1993
Joseph G, Grist S, Firgaira F, Morley A, Turner D
Abstract excerpt
Immunoselection has been used to identify human lymphocytes that have undergone spontaneous mutation resulting in the loss of expression of one of the codominant HLA-A alleles. Approximately 35% of such mutations are the consequence of mitotic recombination events. Mitotic recombination is the result of nonsister chromatid exchange that leaves the mutated cell homozygous for all loci distal to the crossover...
Topics
- Chromosome Mapping
- Chromosomes, Human, Pair 6
- Crossing Over, Genetic
- Evaluation Studies as Topic
- HLA-A Antigens
- Humans
- Lymphocytes
- Mitosis
- Mutation
- Polymorphism, Genetic
- Recombination, Genetic