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Article

False homozygosity results in HLA genotyping due to loss of chromosome 6 in a patient with acute lymphoblastic leukemia.

The Korean journal of laboratory medicine - 1 Oct 2011

Park Hyewon, Hyun Jungwon, Park Sung Sup, Park Myoung Hee, Song Eun Young

Abstract excerpt

Loss of heterozygosity (LOH) in chromosome 6p has been reported in a number of tumors and some hematologic malignancies, including ALL. LOH in chromosome 6p, on which the HLA genes are located, can give rise to false homozygosity results in HLA genotyping of patients with hematologic malignancies. Here we report false homozygosity results in HLA genotyping due to the loss of whole chromosome 6 in the neoplastic...

Topics

Adult
Chromosome Duplication
Chromosomes, Human, Pair 6
Diagnostic Errors
Female
Genotype
HLA Antigens
Hematopoietic Stem Cell Transplantation
Humans
Karyotyping
Leukocyte Count

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Loss of Heterozygosity

Nerve Tissue Proteins

Precursor Cell Lymphoblastic Leukemia-Lymphoma

RNA-Binding Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 22016688
DOI: 10.3343/kjlm.2011.31.4.302
PMCID: PMC3190013

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