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Article

Mitotic recombination map of 13cen-13q14 derived from an investigation of loss of heterozygosity in retinoblastomas.

Proceedings of the National Academy of Sciences of the United States of America - 16 Mar 1999

Hagstrom S A, Dryja T P

Abstract excerpt

Loss of heterozygosity at tumor-suppressor loci is an important oncogenic mechanism first discovered in retinoblastomas. We explored this phenomenon by examining a set of matched retinoblastoma and leukocyte DNA samples from 158 patients informative for DNA polymorphisms. Loss of heterozygosity at the retinoblastoma locus (13q14) was observed in 101 cases, comprising 7 cases with a somatic deletion causing...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 10077618
DOI: 10.1073/pnas.96.6.2952
PMCID: PMC15876

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Source receipt: pubmed, retrieved 7 Sept 2026.

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