Molecular nature of in vivo mutations in human cells at the autosomal HLA-A locus.

Article

Molecular nature of in vivo mutations in human cells at the autosomal HLA-A locus.

Cancer research - 1 Aug 1990

Morley A A, Grist S A, Turner D R, Kutlaca A, Bennett G

Abstract excerpt

The mutations present in vivo in normal human cells were studied at the HLA-A locus by isolating mutant lymphocytes using antibody-complement immunoselection and cloning at limiting dilution. The molecular basis for mutation in 127 mutant lymphocytes from 10 individuals was determined by studying...

Topics

Cells, Cultured
Chromosome Deletion
Chromosome Mapping
Chromosomes, Human, Pair 6
Genetic Carrier Screening
Genetic Markers
Glutathione Transferase
HLA-A Antigens
Humans
Lymphocytes
Mitosis
Mutation
Recombination, Genetic

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