Article
Further evidence for function of the Drosophila Notch protein as a transmembrane receptor.
Proceedings of the National Academy of Sciences of the United States of America - 1 Nov 1993
Lyman D, Young M W
Abstract excerpt
N locus mutations associated with unusual mutant phenotypes were found to alter the structure of the encoded protein. Two mutations, NCo and N60g11, eliminate much of the cytoplasmic domain. NCo can act as a null allele or as a competitive inhibitor of N+ function, whereas N60g11 produces dominan...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Cell Membrane
- Cloning, Molecular
- Drosophila Proteins
- Drosophila melanogaster
- Genotype
- Homozygote
- Insect Hormones
- Membrane Proteins
- Molecular Sequence Data
- Mutagenesis
- Mutagenesis, Site-Directed
- Phenotype
- Receptors, Notch
- Restriction Mapping
- Sequence Deletion