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Article

Regulation of Notch signaling by glycosylation.

Current opinion in structural biology - 1 Oct 2007

Stanley Pamela

Abstract excerpt

Notch receptors are approximately 300 kDa cell surface glycoproteins whose activation by Notch ligands regulates cell fate decisions in the metazoa. The extracellular domain of Notch receptors has many epidermal growth factor like repeats that are glycosylated with O-fucose and O-glucose glycans as well as N-glycans. Disruption of O-fucose glycan synthesis leads to severe Notch signaling defects in Drosophila and...

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Identifiers

PMID: 17964136
DOI: 10.1016/j.sbi.2007.09.007
PMCID: PMC2141538

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Regulation of Notch signaling by glycosylation.PMID 17964136Read ↗

Roles of O-fucose glycans in notch signaling revealed by mutant mice.Semantic proximity Read ↗

Contribution of extracellular O-GlcNAc to the stability of folded epidermal growth factor-like domains and Notch1 trafficking.Semantic proximity Read ↗

Notch signaling in development and disease.Semantic proximity Read ↗

Regulation of notch signaling by o-linked fucose.Semantic proximity Read ↗

Two pathways for importing GDP-fucose into the endoplasmic reticulum lumen function redundantly in the O-fucosylation of Notch in Drosophila.Semantic proximity Read ↗

Highly conserved O-fucose sites have distinct effects on Notch1 function.Semantic proximity Read ↗

Diseases related to Notch glycosylationSemantic proximity Read ↗

Negative regulation of notch signaling by xylose.Semantic proximity Read ↗

Notch deficiency implicated in the pathogenesis of congenital disorder of glycosylation IIc.Semantic proximity Read ↗

Functional analysis of glycosylation using Drosophila melanogaster.Semantic proximity Read ↗

Rescue of Notch signaling in cells incapable of GDP-L-fucose synthesis by gap junction transfer of GDP-L-fucose in Drosophila.Semantic proximity Read ↗

Protein O-GlcNAcylation is required for fibroblast growth factor signaling in Drosophila.Semantic proximity Read ↗

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