Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ca(2+)-ATPase function is required for intracellular trafficking of the Notch receptor in Drosophila.

The EMBO journal - 1 Nov 1999

Periz G, Fortini M E

Abstract excerpt

Maintaining high Ca(2+) concentrations in the lumen of the endoplasmic reticulum is important for protein synthesis and transport. We identified a lethal complementation group recovered in a screen for mutations that reduce Notch activity as loss-of-function alleles of the Drosophila Ca(2+)-ATPase gene Ca-P60A. Analysis of Ca-P60A mutants indicates that Ca(2+)-ATPase is essential for cell viability and tissue...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calcium-Transporting ATPases
Share to Darier Disease
Share to Genes, Insect

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genes, Lethal

Share to Indoles

Share to Microscopy, Electron, Scanning

Share to Receptors, Notch

Share to Thapsigargin

Source

Open in PubMed Open full text

Identifiers

PMID: 10545110
DOI: 10.1093/emboj/18.21.5983
PMCID: PMC1171664

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ca(2+)-ATPase function is required for intracellular trafficking of the Notch receptor in Drosophila.PMID 10545110Read ↗

The vacuolar ATPase is required for physiological as well as pathological activation of the Notch receptor.Semantic proximity Read ↗

The vacuolar proton pump, V-ATPase, is required for notch signaling and endosomal trafficking in Drosophila.Semantic proximity Read ↗

Localization and functions of protein kinase A during Drosophila oogenesis.Semantic proximity Read ↗

Endosomal entry regulates Notch receptor activation in Drosophila melanogaster.Semantic proximity Read ↗

The C. elegans P4-ATPase TAT-1 regulates lysosome biogenesis and endocytosis.Semantic proximity Read ↗

Genetic identification of intracellular trafficking regulators involved in Notch-dependent binary cell fate acquisition following asymmetric cell division.Semantic proximity Read ↗

Dynamic intracellular distribution of Notch during activation and asymmetric cell division revealed by functional fluorescent fusion proteins.Semantic proximity Read ↗

Protein trafficking abnormalities in Drosophila tissues with impaired activity of the ZIP7 zinc transporter Catsup.Semantic proximity Read ↗

Loss of the Atp2c1 secretory pathway Ca(2+)-ATPase (SPCA1) in mice causes Golgi stress, apoptosis, and midgestational death in homozygous embryos and squamous cell tumors in adult heterozygotes.Semantic proximity Read ↗

Activity of the hSPCA1 Golgi Ca2+ pump is essential for Ca2+-mediated Ca2+ response and cell viability in Darier diseaseSemantic proximity Read ↗

An A-kinase anchoring protein is required for protein kinase A regulatory subunit localization and morphology of actin structures during oogenesis in Drosophila.Semantic proximity Read ↗

Disruption of Drosophila melanogaster lipid metabolism genes causes tissue overgrowth associated with altered developmental signaling.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.