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Article

Conformational variability of the intracellular domain of Drosophila Notch and its interaction with Suppressor of Hairless.

Proceedings of the National Academy of Sciences of the United States of America - 5 Jun 2007

Kelly Deborah F, Lake Robert J, Walz Thomas, Artavanis-Tsakonas Spyros

Abstract excerpt

The Notch receptor is the central element in an evolutionarily conserved signal transduction pathway that controls cell fates in metazoans. Receptor-ligand interactions trigger a cascade of proteolytic events that release the entire Notch intracellular domain (NICD) from the membrane, permitting its translocation into the nucleus and participation in a transcriptionally active complex. Using electron microscopy,...

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Identifiers

PMID: 17535912
DOI: 10.1073/pnas.0702887104
PMCID: PMC1887580

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Conformational variability of the intracellular domain of Drosophila Notch and its interaction with Suppressor of Hairless.PMID 17535912Read ↗

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