Antineurogenic phenotypes induced by truncated Notch proteins indicate a role in signal transduction and may point to a novel function for Notch in nuclei.

doi:10.1101/gad.7.10.1949

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Article

Antineurogenic phenotypes induced by truncated Notch proteins indicate a role in signal transduction and may point to a novel function for Notch in nuclei.

Genes & development - 1 Oct 1993

Lieber T, Kidd S, Alcamo E, Corbin V, Young M W

Abstract excerpt

Loss of any one of several neurogenic genes of Drosophila results in overproduction of embryonic neuroblasts at the expense of epidermoblasts. In this paper a variety of altered Notch proteins are expressed in transgenic flies. Dominant lethal, antineurogenic phenotypes were produced by expressio...

Topics

Animals
Animals, Genetically Modified
Cell Compartmentation
Cell Cycle Proteins
Cell Nucleus
Cysteine
DNA Mutational Analysis
Drosophila
Drosophila Proteins
Epidermal Growth Factor
Fungal Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genes, Insect

Immunohistochemistry

Insect Hormones

Membrane Proteins

Nerve Tissue

Peptide Fragments

Phenotype

Source

Open in PubMed

Identifiers

PMID: 8406001
DOI: 10.1101/gad.7.10.1949

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8406001-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Antineurogenic phenotypes induced by truncated Notch proteins indicate a role in signal transduction and may point to a novel function for Notch in nuclei.PMID 8406001Read ↗

Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants.Semantic proximity Read ↗

A role for the Drosophila neurogenic genes in mesoderm differentiation.Semantic proximity Read ↗

Evidence for the involvement of dominant-negative Notch molecules in the normal course of Drosophila development.Semantic proximity Read ↗

Analysis of phenotypic abnormalities and cell fate changes caused by dominant activated and dominant negative forms of the Notch receptor in Drosophila development.Semantic proximity Read ↗

The Drosophila Hem/Kette/Nap1 protein regulates asymmetric division of neural precursor cells by regulating localization of Inscuteable and Numb.Semantic proximity Read ↗

Specific truncations of Drosophila Notch define dominant activated and dominant negative forms of the receptor.Semantic proximity Read ↗

A member of the Notch group of interacting loci, deltex encodes a cytoplasmic basic protein.Semantic proximity Read ↗

Insensible is a novel nuclear inhibitor of Notch activity in Drosophila.Semantic proximity Read ↗

Cytosolic interaction between deltex and Notch ankyrin repeats implicates deltex in the Notch signaling pathway.Semantic proximity Read ↗

Differential effects of Drosophila mastermind on asymmetric cell fate specification and neuroblast formation.Semantic proximity Read ↗

Further evidence for function of the Drosophila Notch protein as a transmembrane receptor.Semantic proximity Read ↗

The Drosophila neurogenic gene big brain, which encodes a membrane-associated protein, acts cell autonomously and can act synergistically with Notch and Delta.Semantic proximity Read ↗

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