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Article

Antineurogenic phenotypes induced by truncated Notch proteins indicate a role in signal transduction and may point to a novel function for Notch in nuclei.

Genes & development - 1 Oct 1993

Lieber T, Kidd S, Alcamo E, Corbin V, Young M W

Abstract excerpt

Loss of any one of several neurogenic genes of Drosophila results in overproduction of embryonic neuroblasts at the expense of epidermoblasts. In this paper a variety of altered Notch proteins are expressed in transgenic flies. Dominant lethal, antineurogenic phenotypes were produced by expression of three classes of mutant proteins: (1) a protein comprised of the cytoplasmic domain of Notch and devoid of...

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PMID: 8406001
DOI: 10.1101/gad.7.10.1949

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Antineurogenic phenotypes induced by truncated Notch proteins indicate a role in signal transduction and may point to a novel function for Notch in nuclei.PMID 8406001Read ↗

Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants.Semantic proximity Read ↗

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The Drosophila Hem/Kette/Nap1 protein regulates asymmetric division of neural precursor cells by regulating localization of Inscuteable and Numb.Semantic proximity Read ↗

Specific truncations of Drosophila Notch define dominant activated and dominant negative forms of the receptor.Semantic proximity Read ↗

A member of the Notch group of interacting loci, deltex encodes a cytoplasmic basic protein.Semantic proximity Read ↗

Insensible is a novel nuclear inhibitor of Notch activity in Drosophila.Semantic proximity Read ↗

Cytosolic interaction between deltex and Notch ankyrin repeats implicates deltex in the Notch signaling pathway.Semantic proximity Read ↗

Differential effects of Drosophila mastermind on asymmetric cell fate specification and neuroblast formation.Semantic proximity Read ↗

Further evidence for function of the Drosophila Notch protein as a transmembrane receptor.Semantic proximity Read ↗

The Drosophila neurogenic gene big brain, which encodes a membrane-associated protein, acts cell autonomously and can act synergistically with Notch and Delta.Semantic proximity Read ↗

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