Article
Roles of O-fucose glycans in notch signaling revealed by mutant mice.
Methods in enzymology - 1 Jan 2006
Lu Linchao, Stanley Pamela
Abstract excerpt
Notch receptor signaling is important for many developmental processes in the metazoa. Insights into how Notch receptor signaling is regulated have been obtained from the characterization of mutants of model organisms in which Notch signaling is perturbed. Here we describe the effects of mutations that alter the glycosylation of Notch receptors and Notch ligands in the mouse. The extracellular domain of Notch...
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