Article
Identification of a Paralog-Specific Notch1 Intracellular Domain Degron.
Cell reports - 31 May 2016
Broadus Matthew R, Chen Tony W, Neitzel Leif R, Ng Victoria H, Jodoin Jeanne N, Lee Laura A, Salic Adrian, Robbins David J, Capobianco Anthony J, Patton James G, Huppert Stacey S, Lee Ethan
Abstract excerpt
Upon Notch pathway activation, the receptor is cleaved to release the Notch intracellular domain (NICD), which translocates to the nucleus to activate gene transcription. Using Xenopus egg extracts, we have identified a Notch1-specific destruction signal (N1-Box). We show that mutations in the N1-Box inhibit NICD1 degradation and that the N1-Box is transferable for the promotion of degradation of heterologous...
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