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Article

Structure-function analysis of delta trafficking, receptor binding and signaling in Drosophila.

Genetics - 1 Dec 2006

Parks Annette L, Stout Jane R, Shepard Scott B, Klueg Kristin M, Dos Santos Ana A, Parody Todd R, Vaskova Martina, Muskavitch Marc A T

Abstract excerpt

The transmembrane proteins Delta and Notch act as ligand and receptor in a conserved signaling pathway required for a variety of cell fate specification events in many organisms. Binding of Delta to Notch results in a proteolytic cascade that releases the Notch intracellular domain, allowing it to participate in transcriptional activation in the nucleus. Recent research has implicated the endocytic and...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17028337
DOI: 10.1534/genetics.106.061630
PMCID: PMC1698634

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Structure-function analysis of delta trafficking, receptor binding and signaling in Drosophila.PMID 17028337Read ↗

Functional Studies of Genetic Variants Associated with Human Diseases in Notch Signaling-Related Genes Using Drosophila.Semantic proximity Read ↗

Endocytic internalization routes required for delta/notch signaling.Semantic proximity Read ↗

Drosophila Epsin's role in Notch ligand cells requires three Epsin protein functions: the lipid binding function of the ENTH domain, a single Ubiquitin interaction motif, and a subset of the C-terminal protein binding modules.Semantic proximity Read ↗

A mutation in EGF repeat-8 of Notch discriminates between Serrate/Jagged and Delta family ligands.Semantic proximity Read ↗

Delta-like 1-Lysine613 regulates notch signaling.Semantic proximity Read ↗

Notch signaling in development and disease.Semantic proximity Read ↗

Ligand endocytosis drives receptor dissociation and activation in the Notch pathway.Semantic proximity Read ↗

The Drosophila melanogaster Suppressor of deltex gene, a regulator of the Notch receptor signaling pathway, is an E3 class ubiquitin ligase.Semantic proximity Read ↗

Either part of a Drosophila epsin protein, divided after the ENTH domain, functions in endocytosis of delta in the developing eye.Semantic proximity Read ↗

Low-density-lipoprotein-receptor-related protein 1 mediates Notch pathway activationSemantic proximity Read ↗

Roles of Drosophila deltex in Notch receptor endocytic trafficking and activation.Semantic proximity Read ↗

Drosophila Tel2 is expressed as a translational fusion with EpsinR and is a regulator of wingless signaling.Semantic proximity Read ↗

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