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Search for the Function of NWC, Third Gene Within RAG Locus: Generation and Characterization of NWC-Deficient Mice.

Archivum immunologiae et therapiae experimentalis - 1 Aug 2016

Kasztura Monika, Sniezewski Lukasz, Laszkiewicz Agnieszka, Majkowski Michal, Kobak Kamil, Peczek Karolina, Janik Sylwia, Kapusniak Violetta, Miazek Arkadiusz, Cebrat Malgorzata, Kisielow Pawel

Abstract excerpt

NWC is a third gene within recombination activating gene (RAG) locus, which unlike RAG genes is ubiquitously expressed and encodes a unique protein containing three strongly evolutionarily conserved domains not found in any other known protein. To get insight into its function we identified several proteins co-immunoprecipitating with NWC protein and generated new NWC-deficient mice. Here, we present evidence...

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Identifiers

PMID: 26703212
DOI: 10.1007/s00005-015-0379-1
PMCID: PMC4939155

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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