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Article

Exploiting structural differences among heteroduplex molecules to simplify genotyping the DQA1 and DQB1 alleles in human lymphocyte typing.

Nucleic acids research - 25 Sept 1993

Zimmerman P A, Carrington M N, Nutman T B

Abstract excerpt

A novel approach to DNA probe hybridization and heteroduplex analysis, termed directed heteroduplex analysis (DHDA) is presented here to illustrate its utility in simplification of human lymphocyte antigen (HLA)-typing. By strategic labeling of single-stranded probe sequences, DHDA allows the identification of specific heteroduplex structures that contribute to the differentiation of DQA1 and DQB1 alleles....

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Identifiers

PMID: 8233788
DOI: 10.1093/nar/21.19.4541
PMCID: PMC311187

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