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Article

Subgrouping of DR4 alleles by DNA heteroduplex analysis.

Human immunology - 1 Jan 1992

Sorrentino R, Cascino I, Tosi R

Abstract excerpt

Amplified DNA molecules from six DR4 alleles at the DRB1 locus were denatured and cross-hybridized pairwise. Several of the DNA heteroduplexes thus generated were found to possess distinct mobilities in polyacrylamide gel electrophoresis. The degree of retardation as compared to homoduplexes depends strongly on the position of mismatched nucleotide pairs. In critical positions, the type of mispairing also...

Topics

Alleles
Base Sequence
Cell Line
DNA
Electrophoresis, Polyacrylamide Gel
Gene Amplification
HLA-DR4 Antigen
Humans
Molecular Sequence Data
Nucleic Acid Heteroduplexes

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 1548147
DOI: 10.1016/0198-8859(92)90047-q

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1548147-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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