The paradox of MHC-DRB exon/intron evolution: alpha-helix and beta-sheet encoding regions diverge while hypervariable intronic simple repeats coevolve with beta-sheet codons.

doi:10.1007/BF00175503

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Article

The paradox of MHC-DRB exon/intron evolution: alpha-helix and beta-sheet encoding regions diverge while hypervariable intronic simple repeats coevolve with beta-sheet codons.

Journal of molecular evolution - 1 Sept 1993

Schwaiger F W, Weyers E, Epplen C, Brün J, Ruff G, Crawford A, Epplen J T

Abstract excerpt

Twenty-one different caprine and 13 ovine MHC-DRB exon 2 sequences were determined including part of the adjacent introns containing simple repetitive (gt)n(ga)m elements. The positions for highly polymorphic DRB amino acids vary slightly among ungulates and other mammals. From man and mouse to u...

Topics

Alleles
Amino Acid Sequence
Animals
Biological Evolution
Codon
Exons
Genes, MHC Class II
Goats
HLA-DR Antigens
Histocompatibility Antigens Class II
Humans
Introns
Mammals
Mice
Molecular Sequence Data

Source

Open in PubMed

Identifiers

PMID: 8230250
DOI: 10.1007/BF00175503

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8230250-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Phylogeny

Polymorphism, Genetic

Protein Structure, Secondary