Article
Exonic polymorphism vs intronic simple repeat hypervariability in MHC-DRB genes.
Immunogenetics - 1 Jan 1992
Ammer H, Schwaiger F W, Kammerbauer C, Gomolka M, Arriens A, Lazary S, Epplen J T
Abstract excerpt
Gene products encoded by the major histocompatibility complex often exhibit a high degree of polymorphism. In humans the HLA-DR polymorphism is due to more than 50 alleles with varying exon 2 sequences. Each group of DRB alleles contains a certain form of the basic simple repeat motif (gt)n(ga)m in intron 2. Identical alleles can be differentiated on the basis of the hypervariable repeat. In this study focused on...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Base Sequence
- Cattle
- Exons
- Genetic Variation
- Histocompatibility Antigens Class I
- Introns
- Molecular Sequence Data
- Multigene Family