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Article

Genetic diversity at class II DRB loci of the primate MHC.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 1991

Gyllensten U, Sundvall M, Ezcurra I, Erlich H A

Abstract excerpt

The evolution of polymorphism at loci encoding the beta-chains of the MHC class II DR Ag was studied in primates by DNA amplification (polymerase chain reaction). Phylogenetic analysis of 63 DRB sequences from the polymorphic second exon (first domain) of nonhuman primates and 53 human sequences indicates the presence of five DRB loci in primates, derived from a DRB1-like ancestral locus over 20 million yr ago....

Topics

Amino Acid Sequence
Animals
Biological Evolution
Chromosome Mapping
Exons
Genetic Variation
HLA-DR Antigens
Haplotypes
Humans
Macaca mulatta
Molecular Sequence Data
Pan troglodytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Papio

Polymorphism, Genetic

Protein Conformation

Recombination, Genetic

Source

Identifiers

PMID: 2040804

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2040804-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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