Ancient, highly polymorphic human major histocompatibility complex DQA1 intron sequences.

doi:10.1002/ajmg.1320520409

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Article

Ancient, highly polymorphic human major histocompatibility complex DQA1 intron sequences.

American journal of medical genetics - 1 Oct 1994

McGinnis M D, Lebo R V, Quinn D L, Simons M J

Abstract excerpt

A 438 basepair intron 1 sequence adjacent to exon 2 in the human major histocompatibility complex DQA1 gene defined 16 allelic variants in 69 individuals from wide ethnic backgrounds. In contrast, the most variable coding region spanned by the 247 basepair exon 2 defined 11 allelic variants. Our phylogenetic human intron 1 tree derived by the Bootstrap algorithm reflects the same relative allelic relationships as...

Topics

Algorithms
Alleles
Animals
Base Sequence
Biological Evolution
Exons
Genetics, Population
HLA-DQ Antigens
Haplotypes
Humans
Introns
Macaca mulatta

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Major Histocompatibility Complex

Molecular Sequence Data

Polymerase Chain Reaction

Polymorphism, Genetic

Racial Groups

Sequence Analysis, DNA

Source

Open in PubMed

Identifiers

PMID: 7747756
DOI: 10.1002/ajmg.1320520409

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7747756-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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