Article
Coding versus intron variability: extremely polymorphic HLA-DRB1 exons are flanked by specific composite microsatellites, even in distant populations.
Human genetics - 1 Mar 1997
Epplen C, Santos E J, Guerreiro J F, van Helden P, Epplen J T
Abstract excerpt
Although microsatellite typing is the dominant method in genome research and indirect gene diagnosis, precise relationships of exonic and adjacent simple repeat polymorphisms are not known. We investigated exon 2 sequences of HLA-DRB1 genes and their neighbouring (GT)n(GA)m repeats including the...
Topics
- Cloning, Molecular
- Dinucleotide Repeats
- Escherichia coli
- Evolution, Molecular
- Exons
- HLA-DR Antigens
- HLA-DRB1 Chains
- Humans
- Introns
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Polymorphism, Genetic