Article
MHC diversity in Caucasians, investigated using highly heterogeneous noncoding sequence motifs at the DQB1 locus including a retroviral long terminal repeat element, and its comparison to nonhuman primate homologues.
Immunogenetics - 1 Sept 2000
Donner H, Tönjes R R, Bontrop R E, Kurth R, Usadel K H, Badenhoop K
Abstract excerpt
Long terminal repeats (LTRs) are common retrovirus-related sequences spread throughout the human genome. We previously reported the human-specific integration of one LTR (DQLTR3) located 15 kb upstream of HLA DQB1. To elucidate the contribution of retroviral sequences to the variability and phylogenetic background of HLA DQB1 we investigated another LTR (DQLTR13), located 1.3 kb upstream of HLA DQB1, in German...
Topics
- Animals
- Base Sequence
- Cercopithecidae
- DNA, Complementary
- Endogenous Retroviruses
- Genetic Heterogeneity
- Genetic Variation
- HLA-DQ Antigens
- HLA-DQ beta-Chains
- Haplotypes