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Article

Transgenic mouse models that explore the multistep hypothesis of intestinal neoplasia.

The Journal of cell biology - 1 Nov 1993

Kim S H, Roth K A, Moser A R, Gordon J I

Abstract excerpt

SV-40 T antigen (TAg), human K-rasVal12, and a dominant negative mutant of human p53 (p53Ala143) have been expressed singly and in all possible combinations in postmitotic enterocytes distributed throughout the duodenal-colonic axis of 1-12-mo-old FVB/N transgenic mice to assess the susceptibility of this lineage to gene products implicated in the pathogenesis of human gut neoplasia. SV-40 TAg produces re-entry...

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Identifiers

PMID: 8227147
DOI: 10.1083/jcb.123.4.877
PMCID: PMC2200156

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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