Transgenic mouse models that explore the multistep hypothesis of intestinal neoplasia.

doi:10.1083/jcb.123.4.877

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Article

Transgenic mouse models that explore the multistep hypothesis of intestinal neoplasia.

The Journal of cell biology - 1 Nov 1993

Kim S H, Roth K A, Moser A R, Gordon J I

Abstract excerpt

SV-40 T antigen (TAg), human K-rasVal12, and a dominant negative mutant of human p53 (p53Ala143) have been expressed singly and in all possible combinations in postmitotic enterocytes distributed throughout the duodenal-colonic axis of 1-12-mo-old FVB/N transgenic mice to assess the susceptibilit...

Topics

Analysis of Variance
Animals
Antigens, Polyomavirus Transforming
Base Sequence
Carrier Proteins
Cell Differentiation
Cell Division
DNA
Disease Models, Animal
Fatty Acid-Binding Protein 7
Fatty Acid-Binding Proteins
Genes, ras

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Intestinal Mucosa

Intestinal Neoplasms

Intestines

Mice

Mice, Transgenic

Molecular Sequence Data

Source

Open in PubMed Open full text

Identifiers

PMID: 8227147
DOI: 10.1083/jcb.123.4.877
PMCID: PMC2200156

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8227147-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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