Article
A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse.
Science (New York, N.Y.) - 19 Jan 1990
Moser A R, Pitot H C, Dove W F
Abstract excerpt
In a pedigree derived from a mouse treated with the mutagen ethylnitrosourea, a mutation has been identified that predisposes to spontaneous intestinal cancer. The mutant gene was found to be dominantly expressed and fully penetrant. Affected mice developed multiple adenomas throughout the entire intestinal tract at an early age.
Topics
- Adenoma
- Alleles
- Anemia
- Animals
- Ethylnitrosourea
- Female
- Intestinal Neoplasms
- Male
- Mice
- Mice, Inbred AKR
- Mice, Inbred C57BL
- Mice, Mutant Strains
- Mutation