Article
Expression of wild-type and mutant simian virus 40 large tumor antigens in villus-associated enterocytes of transgenic mice.
Proceedings of the National Academy of Sciences of the United States of America - 19 Jul 1994
Kim S H, Roth K A, Coopersmith C M, Pipas J M, Gordon J I
Abstract excerpt
The four principal gut epithelial cell lineages undergo continuous and rapid renewal during a geographically well-organized migration along the crypt-to-villus axis. The molecules that regulate their proliferation and differentiation programs are largely unknown. The large tumor antigen (TAg) of wild-type (wt) simian virus 40 (SV40) and its mutant derivatives represent tools for describing the contributions of...
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