Interaction between murine germline mutations in p53 and APC predisposes to pancreatic neoplasia but not to increased intestinal malignancy.

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Article

Interaction between murine germline mutations in p53 and APC predisposes to pancreatic neoplasia but not to increased intestinal malignancy.

Oncogene - 2 Nov 1995

Clarke A R, Cummings M C, Harrison D J

Abstract excerpt

Murine strains which bear constitutive inactivating mutations of either the APC or the p53 tumor suppressor genes are characterised by spontaneous tumors. APC mutated (Min) mice develop large and small bowel adenomas, a small proportion of which, in time, become malignant. p53 deficient mice deve...

Topics

Adenocarcinoma
Adenoma
Aging
Animals
Base Sequence
Cell Transformation, Neoplastic
Colorectal Neoplasms
DNA Primers
Genes, APC
Genes, p53
Genetic Predisposition to Disease
Genotype
Heterozygote
Humans
Intestinal Neoplasms
Lymphoma
Mice
Mice, Mutant Strains

Source

Open in PubMed

Identifiers

PMID: 7478622

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7478622-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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