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Article

The development of duodenal microadenomas in FAP patients: the human correlate of the Min mouse.

The Journal of pathology - 1 Feb 2008

Preston S L, Leedham S J, Oukrif D, Deheregoda M, Goodlad R A, Poulsom R, Alison M R, Wright N A, Novelli M

Abstract excerpt

UNLABELLED: The morphological changes associated with the adenoma-carcinoma sequence are well documented in the colorectum. Small intestinal carcinogenesis is thought to progress through a similar adenoma-to-carcinoma pathway, but there is a relative dearth of studies examining the associated morphological changes. The best-known mouse model of intestinal neoplasia, the multiple intestinal neoplasia (Min) mouse,...

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Source

Identifiers

PMID: 18085615
DOI: 10.1002/path.2294

Genes

FAP
APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The development of duodenal microadenomas in FAP patients: the human correlate of the Min mouse.PMID 18085615Read ↗

The Min (multiple intestinal neoplasia) mutation: its effect on gut epithelial cell differentiation and interaction with a modifier system.Semantic proximity Read ↗

Microadenomatous lesions involving loss of Apc heterozygosity in the colon of adult Apc(Min/+) mice.Semantic proximity Read ↗

Intestinal adenomas of Min-mice lack enterochromaffin cells, and have increased lysozyme production in non-Paneth cells.Semantic proximity Read ↗

Multistep carcinogenesis of the colon in Apc(Min/+) mouse.Semantic proximity Read ↗

Generation of a unique strain of multiple intestinal neoplasia (Apc+/Min‐FCCC) mice with significantly increased numbers of colorectal adenomasSemantic proximity Read ↗

Qualitative and quantitative relationship between dysplastic aberrant crypt foci and tumorigenesis in the Min/+ mouse colon.Semantic proximity Read ↗

Dysplastic Aberrant Crypt Foci: Biomarkers of Early Colorectal Neoplasia and Response to Preventive Intervention.Semantic proximity Read ↗

Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene.Semantic proximity Read ↗

Deletion of the WNT Target and Cancer Stem Cell Marker CD44 in Apc(Min/+) Mice Attenuates Intestinal TumorigenesisSemantic proximity Read ↗

Duodenal Adenomas and Cancer in MUTYH-associated Polyposis: An International Cohort StudySemantic proximity Read ↗

Gene Expression Changes Accompanying the Duodenal Adenoma-Carcinoma Sequence in Familial Adenomatous PolyposisSemantic proximity Read ↗

Mutated K-ras(Asp12) promotes tumourigenesis in Apc(Min) mice more in the large than the small intestines, with synergistic effects between K-ras and Wnt pathways.Semantic proximity Read ↗

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