Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Loss of p53 enhances the induction of colitis-associated neoplasia by dextran sulfate sodium.

Carcinogenesis - 1 Nov 2007

Chang Wen-Chi L, Coudry Renata A, Clapper Margie L, Zhang Xiaoyan, Williams Kara-Lynn, Spittle Cynthia S, Li Tianyu, Cooper Harry S

Abstract excerpt

Loss of p53 function is an early event in colitis-associated neoplasia in humans. We assessed the role of p53 in a mouse model of colitis-associated neoplasia. Colitis was induced in p53-/-, p53+/- and p53+/+ mice using three or four cycles of dextran sulfate sodium (DSS) followed by 120 days of water. Mice were examined for incidence, multiplicity and types of neoplastic lesions. Lesions were examined for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Colitis
Share to Colorectal Neoplasms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Dextran Sulfate

Share to Mice, Inbred C57BL

Share to Mice, Knockout

Share to Polyploidy

Share to Tumor Suppressor Protein p53

Source

Identifiers

PMID: 17557903
DOI: 10.1093/carcin/bgm134

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Loss of p53 enhances the induction of colitis-associated neoplasia by dextran sulfate sodium.PMID 17557903Read ↗

Development of colonic neoplasia in p53 deficient mice with experimental colitis induced by dextran sulphate sodium.Semantic proximity Read ↗

Dysplasia and cancer in the dextran sulfate sodium mouse colitis model. Relevance to colitis-associated neoplasia in the human: a study of histopathology, B-catenin and p53 expression and the role of inflammation.Semantic proximity Read ↗

Inducible heat shock protein 70 prevents multifocal flat dysplastic lesions and invasive tumors in an inflammatory model of colon cancer.Semantic proximity Read ↗

Mutant p53 prolongs NF-κB activation and promotes chronic inflammation and inflammation-associated colorectal cancer.Semantic proximity Read ↗

p53 at the crossroads of colitis and cancer.Semantic proximity Read ↗

Transgenic mouse models that explore the multistep hypothesis of intestinal neoplasia.Semantic proximity Read ↗

Mutant p53 accumulates in cycling and proliferating cells in the normal tissues of p53 R172H mutant mice.Semantic proximity Read ↗

Analysing p53 tumour suppressor functions in mice.Semantic proximity Read ↗

Intestinal cancer progression by mutant p53 through the acquisition of invasiveness associated with complex glandular formation.Semantic proximity Read ↗

Genetically induced mouse model for colon-specific epithelial cell tumorigenesis driven by loss of K8 and ApcSemantic proximity Read ↗

p53 knockout mice (-/-) are more susceptible than (+/-) or (+/+) mice to N-methyl-N-nitrosourea stomach carcinogenesis.Semantic proximity Read ↗

The role of mutant Apc in the development of dysplasia and cancer in the mouse model of dextran sulfate sodium–induced colitisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.