Article
Absence of p53 gene mutations in primary neuroblastomas.
Cancer research - 1 Nov 1993
Vogan K, Bernstein M, Leclerc J M, Brisson L, Brossard J, Brodeur G M, Pelletier J, Gros P
Abstract excerpt
Neuroblastoma is a common childhood malignancy of the sympathetic nervous system. Mutations in p53, a tumor suppressor gene located on the short arm of chromosome 17, are one of the most common genetic lesions in human cancers. The evidence for trisomies of 17q with loss of 17p in some cases of n...
Topics
- Base Sequence
- Child
- Chromosome Aberrations
- Chromosomes, Human, Pair 17
- Cloning, Molecular
- Codon
- DNA Primers
- Exons
- Genes, p53
- Humans
- Molecular Sequence Data
- Mutation
- Neoplasm Staging
- Neuroblastoma
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Trisomy