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Article

p53 mutations in nonastrocytic human brain tumors.

Cancer research - 15 Nov 1991

Ohgaki H, Eibl R H, Wiestler O D, Yasargil M G, Newcomb E W, Kleihues P

Abstract excerpt

Genomic DNA from 51 primary human brain tumors was screened for the presence of mutations in the tumor suppressor gene, p53, using the polymerase chain reaction and single strand conformation polymorphism analysis, followed by direct DNA sequencing. Mutations leading to an amino acid change were found in 2 of 17 (12%) oligodendrogliomas and 2 of 19 (11%) medulloblastomas but none of 15 ependymomas. Sites of...

Topics

Adult
Alleles
Base Sequence
Brain Neoplasms
Female
Genes, p53
Humans
Male
Molecular Sequence Data
Mutation

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 1933879

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1933879-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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