Article
Wild-type p53 protein undergoes cytoplasmic sequestration in undifferentiated neuroblastomas but not in differentiated tumors.
Proceedings of the National Academy of Sciences of the United States of America - 9 May 1995
Moll U M, LaQuaglia M, Bénard J, Riou G
Abstract excerpt
Neuroblastoma (NB), a tumor arising from the sympathetic nervous system, is one of the most common malignancies in childhood. Several recent reports on the p53 genotype found virtually exclusive wild-type status in primary tumors, and it was postulated that p53 plays no role in the development of...
Topics
- Blotting, Southern
- Cell Differentiation
- Child
- DNA, Complementary
- DNA, Neoplasm
- Ganglioneuroblastoma
- Gene Expression
- Genes, myc
- Genes, p53
- Genotype
- Humans
- Neuroblastoma
- Restriction Mapping
- Tumor Suppressor Protein p53