Article
Absence of p53 gene mutations in primary nasopharyngeal carcinomas.
Cancer research - 1 Sept 1992
Spruck C H, Tsai Y C, Huang D P, Yang A S, Rideout W M, Gonzalez-Zulueta M, Choi P, Lo K W, Yu M C, Jones P A
Abstract excerpt
Alterations in the p53 tumor suppressor gene and Epstein-Barr virus status were investigated in 15 nasopharyngeal carcinoma (NPC) biopsies, 4 xenografts, and 2 cell lines from the Cantonese region of southern China. One other established NPC cell line obtained from a northern Chinese patient was also studied. Restriction fragment length polymorphism analysis revealed a loss of heterozygosity for chromosome 17p,...
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