Article
Frequent loss of 17p, but no p53 mutations or protein overexpression in benign and malignant pheochromocytomas.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Apr 2008
Petri Bart-Jeroen, Speel Ernst-Jan M, Korpershoek Esther, Claessen Sandra M H, van Nederveen Francien H, Giesen Vivian, Dannenberg Hilde, van der Harst Erwin, Dinjens Winand N M, de Krijger Ronald R
Abstract excerpt
Genetic changes in the tumorigenesis of sporadic pheochromocytomas are poorly understood, and there are no good markers to discriminate benign from malignant pheochromocytomas. p53 is a tumor suppressor gene and aberrations in this gene are frequently found in many tumor types. The role of p53 in pheochromocytoma tumorigenesis is unclear, with some studies suggesting that p53 mutations can be used to discriminate...
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