Article
Mutation of the p53 gene in neuroblastoma and its relationship with N-myc amplification.
Cancer research - 1 Sept 1993
Imamura J, Bartram C R, Berthold F, Harms D, Nakamura H, Koeffler H P
Abstract excerpt
Mutation of the p53 tumor suppressor gene frequently occurs in a variety of tumors including lung, breast, gastrointestinal, and brain, as well as lymphomas-leukemias. Neuroblastoma, one of the most common solid tumors in childhood, often has amplification of the N-myc gene. We examined for mutations of the p53 tumor suppressor gene by single-strand conformational polymorphism using polymerase chain reaction...
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