Article
Infrequent p53 gene mutations in medulloblastomas.
Cancer research - 1 Sept 1991
Saylors R L, Sidransky D, Friedman H S, Bigner S H, Bigner D D, Vogelstein B, Brodeur G M
Abstract excerpt
Cytogenetic and molecular studies of medulloblastomas have demonstrated frequent loss of sequences from the short arm of chromosome 17, possibly implicating loss or inactivation of the p53 tumor suppressor gene. We amplified exons 5 through 8 of the p53 gene by the polymerase chain reaction techn...
Topics
- Cerebellar Neoplasms
- Chromosomes, Human, Pair 17
- Genes, p53
- Humans
- Medulloblastoma
- Mutation
- Tumor Cells, Cultured