Article
Absence of p53 mutations in childhood central nervous system primitive neuroectodermal tumors.
Neurosurgery - 1 Aug 1993
Raffel C, Thomas G A, Tishler D M, Lassoff S, Allen J C
Abstract excerpt
The primitive neuroectodermal tumor of the central nervous system is one of a number of tumors in which deletions on chromosome 17p have been identified. The tumor suppressor gene, p53, is located in the region of the deletion. To determine if the p53 gene is involved in the development of primit...
Topics
- Adolescent
- Adult
- Brain
- Central Nervous System Neoplasms
- Child
- Child, Preschool
- Chromosome Aberrations
- Chromosomes, Human, Pair 16
- Combined Modality Therapy
- DNA Probes
- Female
- Humans
- Infant
- Male
- Mutation
- Neoplasm Recurrence, Local
- Neoplasms, Germ Cell and Embryonal
- Polymerase Chain Reaction