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Article

Expression level, allelic origin, and mutation analysis of the p73 gene in neuroblastoma tumors and cell lines.

Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Nov 1998

Kovalev S, Marchenko N, Swendeman S, LaQuaglia M, Moll U M

Abstract excerpt

The novel p73 gene is a structural and, in overexpression systems, functional p53 homologue. p73 resides on chromosome 1p36.33 within a commonly deleted region in neuroblastoma (NB) and other human tumors. To evaluate p73's candidacy for a NB suppressor, we analyzed 28 primary NB tumors, 14 NB cell lines, and 5 non-NB malignant pediatric tumors. We determined the level of p73 expression and its allelic origin and...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 9831242

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Expression level, allelic origin, and mutation analysis of the p73 gene in neuroblastoma tumors and cell lines.PMID 9831242Read ↗

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Stage-independent expression and genetic analysis of tp73 in neuroblastoma.Semantic proximity Read ↗

p73 at chromosome 1p36.3 is lost in advanced stage neuroblastoma but its mutation is infrequentSemantic proximity Read ↗

Differential expression and allelotyping of the p73 gene in neuroblastoma.Semantic proximity Read ↗

When p53 needs p73 to be functional - forced p73 expression induces nuclear accumulation of endogenous p53 protein.Semantic proximity Read ↗

Variable expression and absence of mutations in p73 in primary neuroblastoma tumors argues against a role in neuroblastoma development.Semantic proximity Read ↗

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